{"id":12182,"date":"2016-12-08T12:33:51","date_gmt":"2016-12-08T11:33:51","guid":{"rendered":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/?p=12182"},"modified":"2016-12-08T15:12:34","modified_gmt":"2016-12-08T14:12:34","slug":"prix-nobel-medecine-2016-autophagie","status":"publish","type":"post","link":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/prix-nobel-medecine-2016-autophagie\/","title":{"rendered":"En savoir plus sur l’autophagie (bibliographie)"},"content":{"rendered":"

Le th\u00e8me de l\u2019autophagie<\/a> a \u00e9t\u00e9 r\u00e9cemment plac\u00e9 sous le feu des projecteurs par l\u2019attribution du prix Nobel de m\u00e9decine<\/a> au biochimiste japonais Yoshinori Ohsumi<\/a>, sp\u00e9cialis\u00e9 dans la biologie cellulaire.<\/p>\n

\"yoshinori_osumi_201511\"<\/a>
Photo \u5927\u81e3\u5b98\u623f\u4eba\u4e8b\u8ab2 \u2014 \u5e73\u621027\u5e74\u5ea6\u3000\u6587\u5316\u529f\u52b4\u8005\uff1a\u6587\u90e8\u79d1\u5b66\u7701<\/figcaption><\/figure>\n

L\u2019autophagie<\/strong> (du grec auto-phagie, se manger soi-m\u00eame<\/em>) constitue un processus fondamental, mais \u00e9quivoque, pour la vie des cellules<\/strong> : m\u00e9canisme de r\u00e9sistance et d\u2019autod\u00e9fense, qui permet la survie de la cellule, mais aussi d\u2019autodestruction, qui peut entra\u00eener sa mort. Ainsi, l\u2019autophagie peut emp\u00eacher qu\u2019une cellule devienne canc\u00e9reuse, mais ce m\u00e9canisme peut aussi bien en renforcer la pathologie.<\/p>\n

Le Professeur Yoshinori Ohsumi<\/strong> et son \u00e9quipe ont identifi\u00e9 la majeure partie de la quarantaine de g\u00e8nes (ATG, Autophagy Related Genes<\/em>) indispensables au fonctionnement de l\u2019autophagie, qui fait l\u2019objet actuellement d\u2019une recherche tr\u00e8s active (stimuler ou r\u00e9duire l\u2019autophagie en fonction de ses effets secondaires<\/em>), tant pour les \u00e9quipes japonaises qu\u2019en France, par exemple, avec le CFATG (Club Francophone de l\u2019AuTophagie)<\/a>.<\/p>\n

Nous vous proposons ici une s\u00e9lection de documents r\u00e9cents sur ce th\u00e8me : ouvrages<\/strong> consultables \u00e0 la BIU Sant\u00e9 ou articles<\/strong> de Yoshinori Ohsumi disponibles gratuitement sur internet (classement chronologique<\/em>) :<\/p>\n

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  1. Autophagie\u00a0: autocannibalisme ou autod\u00e9fense\u00a0? – EM|consulte [Internet]. 2016. Disponible sur: http:\/\/www.em-consulte.com\/rmr\/article\/184750<\/a><\/li>\n
  2. Suzuki SW, Yamamoto H, Oikawa Y, Kondo-Kakuta C, Kimura Y, Hirano H, et al. Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation. Proceedings of the National Academy of Sciences [Internet]. 17 mars 2015;112(11):3350\u20115. Disponible sur: http:\/\/www.pnas.org\/lookup\/doi\/10.1073\/pnas.1421092112<\/a><\/li>\n
  3. Sakoh-Nakatogawa M, Kirisako H, Nakatogawa H, Ohsumi Y. Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes. FEBS Letters [Internet]. 12 mars 2015;589(6):744\u20119. Disponible sur: http:\/\/doi.wiley.com\/10.1016\/j.febslet.2015.02.003<\/a><\/li>\n
  4. \n
    Morgan AH, Hammond VJ, Sakoh-Nakatogawa M, Ohsumi Y, Thomas CP, Blanchet F, et al. A novel role for 12\/15-lipoxygenase in regulating autophagy. Redox Biology [Internet]. avr 2015;4:40\u20117. Disponible sur: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213231714001177<\/a><\/div>\n<\/li>\n
  5. \n
    Huang H, Kawamata T, Horie T, Tsugawa H, Nakayama Y, Ohsumi Y, et al. Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast. The EMBO Journal [Internet]. 13 janv 2015;34(2):154\u201168. Disponible sur: http:\/\/emboj.embopress.org\/cgi\/doi\/10.15252\/embj.201489083<\/a><\/div>\n<\/li>\n
  6. \n
    Atzmon G. Longevity genes\u202f: a blueprint for aging. New York Heidelberg Dordrecht [etc.]: Springer; 2015. (Advances in experimental medicine and biology). Consultable au p\u00f4le M\u00e9decine (cote 210602-847)<\/a>.<\/div>\n<\/li>\n
  7. \n
    Yoshimoto K, Shibata M, Kondo M, Oikawa K, Sato M, Toyooka K, et al. Organ-specific quality control of plant peroxisomes is mediated by autophagy. Journal of Cell Science [Internet]. 15 mars 2014;127(6):1161\u20118. Disponible sur: http:\/\/jcs.biologists.org\/cgi\/doi\/10.1242\/jcs.139709<\/a><\/div>\n<\/li>\n
  8. \n
    Tanaka C, Tan L-J, Mochida K, Kirisako H, Koizumi M, Asai E, et al. Hrr25 triggers selective autophagy\u2013related pathways by phosphorylating receptor proteins. The Journal of Cell Biology [Internet]. 13 oct 2014;207(1):91\u2011105. Disponible sur: http:\/\/www.jcb.org\/lookup\/doi\/10.1083\/jcb.201402128<\/a><\/div>\n<\/li>\n
  9. \n
    Suzuki K, Nakamura S, Morimoto M, Fujii K, Noda NN, Inagaki F, et al. Proteomic Profiling of Autophagosome Cargo in Saccharomyces cerevisiae. Seaman M, \u00e9diteur. PLoS ONE [Internet]. 13 mars 2014;9(3):e91651. Disponible sur: http:\/\/dx.plos.org\/10.1371\/journal.pone.0091651<\/a><\/div>\n<\/li>\n
  10. \n
    Ohsumi Y. Historical landmarks of autophagy research. Cell Research [Internet]. janv 2014;24(1):9\u201123. Disponible sur: http:\/\/www.nature.com\/doifinder\/10.1038\/cr.2013.169<\/a><\/div>\n<\/li>\n
  11. \n
    Nakatogawa H, Ohsumi Y. Autophagy: Close Contact Keeps Out the Uninvited. Current Biology [Internet]. juin 2014;24(12):R560\u20112. Disponible sur: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960982214005387<\/a><\/div>\n<\/li>\n
  12. \n
    Mochida K, Ohsumi Y, Nakatogawa H. Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of \u03b1-mannosidase under nitrogen starvation conditions. FEBS Letters [Internet]. 3 nov 2014;588(21):3862\u20119. Disponible sur: http:\/\/doi.wiley.com\/10.1016\/j.febslet.2014.09.032<\/a><\/div>\n<\/li>\n
  13. \n
    Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H, Ohsumi Y. Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. Journal of Cell Science [Internet]. 1 juin 2013;126(11):2534\u201144. Disponible sur: http:\/\/jcs.biologists.org\/cgi\/doi\/10.1242\/jcs.122960<\/a><\/div>\n<\/li>\n
  14. \n
    Shibata M, Oikawa K, Yoshimoto K, Kondo M, Mano S, Yamada K, et al. Highly Oxidized Peroxisomes Are Selectively Degraded via Autophagy in Arabidopsis. The Plant Cell [Internet]. 1 d\u00e9c 2013;25(12):4967\u201183. Disponible sur: http:\/\/www.plantcell.org\/cgi\/doi\/10.1105\/tpc.113.116947<\/a><\/div>\n<\/li>\n
  15. \n
    Araki Y, Ku W-C, Akioka M, May AI, Hayashi Y, Arisaka F, et al. Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. The Journal of Cell Biology [Internet]. 28 oct 2013;203(2):299\u2011313. Disponible sur: http:\/\/www.jcb.org\/lookup\/doi\/10.1083\/jcb.201304123<\/a><\/div>\n<\/li>\n
  16. \n
    Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, et al. Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate. Structure [Internet]. juill 2012;20(7):1244\u201154. Disponible sur: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212612001773<\/a><\/div>\n<\/li>\n
  17. \n
    Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, et al. Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate. Structure [Internet]. juill 2012;20(7):1244\u201154. Disponible sur: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212612001773<\/a><\/div>\n<\/li>\n
  18. \n
    Noda NN, Fujioka Y, Hanada T, Ohsumi Y, Inagaki F. Structure of the Atg12\u2013Atg5 conjugate reveals a platform for stimulating Atg8\u2013PE conjugation. EMBO reports [Internet]. 14 d\u00e9c 2012;14(2):206\u201111. Disponible sur: http:\/\/embor.embopress.org\/cgi\/doi\/10.1038\/embor.2012.208<\/a><\/div>\n<\/li>\n
  19. \n
    Noda NN, Kobayashi T, Adachi W, Fujioka Y, Ohsumi Y, Inagaki F. Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30\/Autophagy-related Protein 6 and Its Specific Role in Autophagy. Journal of Biological Chemistry [Internet]. 11 mai 2012;287(20):16256\u201166. Disponible sur: http:\/\/www.jbc.org\/cgi\/doi\/10.1074\/jbc.M112.348250<\/a><\/div>\n<\/li>\n
  20. \n
    Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, et al. The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation. Journal of Biological Chemistry [Internet]. 17 ao\u00fbt 2012;287(34):28503\u20117. Disponible sur: http:\/\/www.jbc.org\/cgi\/doi\/10.1074\/jbc.C112.387514<\/a><\/div>\n<\/li>\n
  21. \n
    Kondo-Okamoto N, Noda NN, Suzuki SW, Nakatogawa H, Takahashi I, Matsunami M, et al. Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy. Journal of Biological Chemistry [Internet]. 23 mars 2012;287(13):10631\u20118. Disponible sur: http:\/\/www.jbc.org\/cgi\/doi\/10.1074\/jbc.M111.299917<\/a><\/div>\n<\/li>\n
  22. \n
    Kobayashi T, Suzuki K, Ohsumi Y. Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2. FEBS Letters [Internet]. 30 juill 2012;586(16):2473\u20118. Disponible sur: http:\/\/doi.wiley.com\/10.1016\/j.febslet.2012.06.008<\/a><\/div>\n<\/li>\n
  23. \n
    Klionsky DJ. Autophagy in disease and clinical applications\u202f: in vitro systems. Amsterdam: Elsevier; 2012. (Methods in enzymology). Ebook disponible en local sur les postes de la BIU Sant\u00e9<\/a> (et \u00e0 distance avec des codes ENT Paris Descartes).<\/div>\n<\/li>\n
  24. \n
    Kakuta S, Yamamoto H, Negishi L, Kondo-Kakuta C, Hayashi N, Ohsumi Y. Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site. Journal of Biological Chemistry [Internet]. 28 d\u00e9c 2012;287(53):44261\u20119. Disponible sur: http:\/\/www.jbc.org\/lookup\/doi\/10.1074\/jbc.M112.411454<\/a><\/div>\n<\/li>\n
  25. \n
    Fougeray S, Thervet \u00c9, Pallet N, Tharaux P-L, Brouard S, Faure M, et al. R\u00f4le du stress du r\u00e9ticulum endoplasmique et de l\u2019autophagie dans la r\u00e9gulation des r\u00e9ponses immune et angiog\u00e9nique activ\u00e9es par des stress isch\u00e9miques et inflammatoires dans l\u2019\u00e9pith\u00e9lium r\u00e9nal humain. [S.l.]: s.n.; 2012. Texte partiel de la th\u00e8se consultable gratuitement en ligne<\/a>, texte int\u00e9gral disponible sur les postes de la BIU Sant\u00e9.<\/div>\n<\/li>\n
  26. \n
    Bouvier N, Thervet \u00c9, Pallet N, Hurault de Ligny B, Hauet T, Chevet E, et al. Cons\u00e9quences r\u00e9nales de l\u2019activation de la r\u00e9ponse UPR (Unfolded protein response) par des stress toxique et isch\u00e9mique. [S.l.]: s.n.; 2012. Th\u00e8se consultable gratuitement en ligne<\/a>.<\/div>\n<\/li>\n
  27. \n
    Tuloup-Minguez V, Codogno P. Autophagie et adh\u00e9rence cellulaire\u202f: r\u00e9gulation par la matrice extracellulaire et r\u00f4le au cours de la migration. [S.l.]: s.n.; 2011. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8383<\/a>.<\/div>\n<\/li>\n
  28. \n
    Magnaudeix A, Yardin C, Terro F. Autophagie dans le syst\u00e8me nerveux central et neuroprotections. [S.l.]: s.n.; 2011. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8183<\/a>.<\/div>\n<\/li>\n
  29. \n
    Dortet L, Cossart P. Recrutement de la Major Vault Protein par InlK\u202f: une nouvelle strat\u00e9gie \u00e9labor\u00e9e par Listeria monocytogenes pour \u00e9chapper \u00e0 l\u2019autophagie. [S.l.]: s.n.; 2011. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8943<\/a>.<\/div>\n<\/li>\n
  30. \n
    Coux O, Baldin V, Bossis G, Temp\u00e9 D, Lalmanach G. Prot\u00e9asome, ubiquitine et prot\u00e9ines apparent\u00e9es \u00e0 l\u2019ubiquitine. Paris: \u00c9d. Tec & Doc; 2011. Consultable au p\u00f4le M\u00e9decine (cote QU 55 PRO) et au p\u00f4le Pharmacie (cote 572.64 COU)<\/a>.<\/div>\n<\/li>\n
  31. \n
    Puissant A, Auberger P. Exploration des m\u00e9canismes de r\u00e9sistance aux inhibiteurs de BCR-ABL dans la leuc\u00e9mie my\u00e9lo\u00efde chronique\u202f: cibler l\u2019autophagie pour ouvrir la voie \u00e0 de nouvelles strat\u00e9gies anti-leuc\u00e9miques. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 7880<\/a>.<\/div>\n<\/li>\n
  32. \n
    Geeraert C, Po\u00fcs C. R\u00f4le des microtubules et de la kin\u00e9sine-1 dans l\u2019autophagie de survie. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 9202<\/a>.<\/div>\n<\/li>\n
  33. \n
    Chotechuang N, Tom\u00e9 D. The role of amino acids in liver protein metabolism under a high protein diet\u202f: identification of amino acids signal and associated transduction pathways. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8007<\/a>.<\/div>\n<\/li>\n
  34. \n
    Chaumorcel M, Servin A. R\u00e9gulation des m\u00e9canismes d\u2019autophagie par les herpesviridae\u202f: l\u2019exemple du cytom\u00e9galovirus humain. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 9190<\/a>.<\/div>\n<\/li>\n
  35. \n
    Ben-Sahra I, Bost F. M\u00e9tabolisme et cancer\u202f: cibler le m\u00e9tabolisme des cellules canc\u00e9reuses par des agents inducteurs du stress m\u00e9tabolique. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 7738<\/a>.<\/div>\n<\/li>\n
  36. \n
    Altmeyer A, Bischoff P. Mort cellulaire induite par des radiations ionisantes dans des tumeurs humaines radior\u00e9sistantes\u202f: Etude, in vitro et in vivo, des m\u00e9canismes impliqu\u00e9s dans son induction par diff\u00e9rents types de rayonnements et modulation pharmacologique. [S.l.]: s.n.; 2010. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 9052<\/a>.<\/div>\n<\/li>\n
  37. \n
    Piron B, Pouget J-P. Etude in vitro des m\u00e9canismes d\u2019action impliqu\u00e9s dans la r\u00e9ponse cellulaire \u00e0 une radioimmunoth\u00e9rapie \u00e0 l\u2019iode 125. [S.l.]: s.n.; 2009. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8446<\/a>.<\/div>\n<\/li>\n
  38. \n
    Pallet N, Thervet \u00c9. R\u00f4le du stress du reticulum endoplasmique dans la n\u00e9phrotoxicit\u00e9 de la ciclosporine. [S.l.]: s.n.; 2009. Th\u00e8se consultable au p\u00f4le Pharmacie, cote TPHA 11510<\/a>.<\/div>\n<\/li>\n
  39. \n
    Levine B, Yoshimori T, Deretic V. Autophagy in infection and immunity. Berlin London: Springer; 2009. (Current topics in microbiology and immunology). Consultable au p\u00f4le M\u00e9decine (cote <\/a>111357-335).<\/a><\/div>\n<\/li>\n
  40. \n
    Hatchi E, Sardet C, Le Cam L. D\u00e9termination des fonctions in vivo d\u2019E4F1 au cours de la tumorigen\u00e8se\u202f: E4F1 un facteur essentiel \u00e0 la survie des cellules transform\u00e9es. [Montpellier]: Universit\u00e9 de Montpellier 2 Sciences et Techniques du Languedoc; 2009. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 7966<\/a>.<\/div>\n<\/li>\n
  41. \n
    Dupont N, Lafont F. Voies de signalisation cellulaire impliqu\u00e9es dans les \u00e9tapes pr\u00e9coces de l\u2019infection par Shigella flexneri dans les cellules \u00e9pith\u00e9liales\u202f: r\u00f4le des d\u00e9bris membranaires de la vacuole de Shigella flexneri dans la signalisation de la cellule eucaryote. [S.l.]: s.n.; 2009. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8151<\/a>.<\/div>\n<\/li>\n
  42. \n
    Chargui A, Poujeol P, El May MV. Adaptations de la cellule r\u00e9nale en r\u00e9ponse au Cadmium\u202f: r\u00f4les du CFTR, de la polyubiquitination sur la Lysine 63 et de l\u2019autophagie \u00e9tudes in vivo et in vitro applications en sant\u00e9 publique. [S.l.]: s.n.; 2009. Th\u00e8se consultable au p\u00f4le Pharmacie, cote MFTH 8305<\/a>.<\/div>\n<\/li>\n<\/ol>\n

    Emmanuelle Pr\u00e9vost<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Le th\u00e8me de l\u2019autophagie a \u00e9t\u00e9 r\u00e9cemment plac\u00e9 sous le feu des projecteurs par l\u2019attribution du prix Nobel de m\u00e9decine au biochimiste japonais Yoshinori Ohsumi, sp\u00e9cialis\u00e9 dans la biologie cellulaire. L\u2019autophagie (du grec auto-phagie, se manger soi-m\u00eame) constitue un processus fondamental, mais \u00e9quivoque, pour la vie des cellules : m\u00e9canisme de r\u00e9sistance et d\u2019autod\u00e9fense, qui … Continuer la lecture de « En savoir plus sur l’autophagie (bibliographie) »<\/span><\/a><\/p>\n","protected":false},"author":27,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[14],"tags":[65,97,317,147],"class_list":["post-12182","post","type-post","status-publish","format-standard","hentry","category-medecine-odontologie","tag-bibliographie","tag-biologie","tag-japon","tag-prix"],"_links":{"self":[{"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/posts\/12182"}],"collection":[{"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=12182"}],"version-history":[{"count":21,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/posts\/12182\/revisions"}],"predecessor-version":[{"id":12590,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/posts\/12182\/revisions\/12590"}],"wp:attachment":[{"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=12182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=12182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/numerabilis.u-paris.fr\/medica\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=12182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}